Research Technician B

Our laboratory studies glioblastoma (GBM), the most common and aggressive primary malignant brain tumor. We investigate both the local tumor microenvironment and systemic immune alterations associated with GBM to understand how the brain and primary and secondary immune organs dynamically influence one another during tumor progression.

Our work has demonstrated that brain tumors induce significant systemic immune remodeling, including thymic and splenic involution, sequestration of T cells in the bone marrow, and expansion of myelopoiesis within the skull marrow. These findings support the concept that GBM is not solely a localized brain disease, but one that actively reshapes systemic immunity.

The laboratory aims to identify and characterize cellular populations recruited to the tumor from the skull marrow and peripheral circulation, define those with antitumoral properties, and develop strategies to therapeutically harness these immune populations to improve GBM treatment.

The technician participates in supporting these animal-based and immunological research studies.

The person will:

• Perform a moderate number of simple or moderate technical procedures;

                                   * mouse breeding

                                   * colony maintenance

                                   * PCR genotyping

                                    * Histological sectioning and immunostaining

                                   * Sample preparation for flow cytometry

• Require occasional guidance;
• Occasionally be responsible for ordering routine supplies;
• Rarely modify technical procedures;
• Rarely train other lab members;
• Rarely guide other lab members;
• A simple / limited understanding of scientific literature and the research goals and rationale is required;
• Occasionally analyze data;
• Rarely interpret data;
• Rarely make written contributions to papers and grant proposals.*

*May not be applicable.

Required to have at least a Bachelor’s Degree in a related science or equivalent skills and related experience, and zero to two years of related experience.